CARBONIC ANHYDRASE IX

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CARBONIC ANHYDRASE IX

Pack Size Cat No
0.2 mL Concentrate MM143-AA
1.0 mL Concentrate MM143-CC
3.0 mL Predilute MM143-3D
6.0 mL Predilute MM143-6D
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Description

Recognizes a glycoprotein of ~200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Carbonic Anhydrases (CAs) are members of a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes, including respiration, calcification, acid-base
balance, bone resorption and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric juice. They show extensive diversity in distribution and in their subcellular localization. CA IX is specifically expressed in clear-cell renal carcinomas.

Specifications

Alternative Name CA9, G250, MN
Species Mouse
Clone CA9/781
Isotype IgG2b Kappa
Dilution Range Assay dependent
Species Reactivity Human, Horse
Application IHC
Cell Localization Nucleus and Cell membrane
Positive Control Renal Cell Carcinoma & Human kidney

DataSheet & SDS

Download Data Sheet
Download SDS Sheet

References

1. Stephen K. Chia et al, Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma, Journal of  Clinical Oncology, 2001  August.

2. JuhaSaarnio et al, Immunohistochemical Study of Colorectal Tumors for Expression of  a Novel Transmembrane Carbonic Anhydrase, MN/CA IX, with Potential Value as a  Marker of Cell Proliferation. The American Journal of Pathology, 1998 July.

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