| Pack Size | Cat No |
|---|---|
| 0.2 mL Concentrate | MM005-AA |
| 1.0 mL Concentrate | MM005-CC |
| 3.0 mL Predilute | MM005-3D |
| 6.0 mL Predilute | MM005-6D |
The CD20 is a 33kDa cell surface antigen exists in four iso forms. It is encoded by a MS4A1 gene. Activation of CD20 increases the DNA synthesis significantly.CD20 functions as a calcium permeable cation channel.CD20 is used as a therapeutic antibody where it helps in the depletion of B cell to treat various forms of cancers and auto immune diseases. It is approved to treat CD20 B cell malignancies leukemia.
| Alternative Name | MS4A1, CD20 |
| Species | Mouse |
| Clone | L26 + IGEL/773 |
| Isotype | Mouse IgG |
| Dilution Range | Assay dependent |
| Species Reactivity | Human, Baboon, Monkey, Dog, Pig, Rat. |
| Application | IHC |
| Cell Localization | Cytoplasmic domain |
| Positive Control | Tonsil & Lymphoma of B-cell |
1. Chadburn A et al, Paraffin-resistant antigens detectable by antibodies L26 and polyclonal CD3 predict the B- or Tcell lineage of 95% of diffuse aggressive non-Hodgkin's lymphomas, Am J Clin Pathol. 1994 Sep.
2. Feng Shi et al, Primary splenic B-cell lymphoma,
unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report, Oncology letters, 2016 July.
3. van Meerten T et al, CD20-targeted therapy: the next
generation of antibodies. Semin Hematol. 2010 Apr.
