Description

CD3+CD20 antibody cocktail reveals lymphoid architecture in neoplastic situations. CD3 consists of five different polypeptide chains  (gamma, delta, epsilon, zeta, and eta).CD3 is involved in T cell development and survival and is expressed in Thymus, peripheral lymphoid tissue, blood and bone marrow.CD3 antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by normal and neoplastic T-lymphocytes. It stains human T-lymphocytes in both cortex and medulla of the thymus and in peripheral lymphoid tissues. CD20 is a non-Ig differentiation antigen of B-lymphocytes and the expression of CD20 is restricted to normal and neoplastic B-lymphocytes, being absent from all other leukocytes and tissues.