Description
The CD34 antigen is a single chain transmembrane glycoprotein with a molecular weight of 110 kD. The CD34 protein is selectively expressed on human lymphoid and myeloid hemopoietic progenitor cells. The CD34 antigen is also expressed on vascular enothelium. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. Approximately 60% of acute Blymphoid leukemias and acute myeloid leukemias (AMLs) express the CD34 antigen. The antigen is not expressed on chronic lymphoid leukemias or lymphomas.
References
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