Description

Chromogranin A is present in neuroendocrine cells throughout the body. Chromogranin A, also known as parathyroid secretory protein 1, or CGA is a secretory protein and a member of the granin family. In humans it is encoded by the gene, CHGA. It is translated as a ~460 amino acid protein of mass 70-85 kDa, but it can be further processed into smaller biologically active neuroendocrine peptides. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.