CYTOKERATIN 8

CYTOKERATIN 8

Pack Size Cat No
0.2 mL Concentrate MM098-AA
1.0 mL Concentrate MM098-CC
3.0 mL Predilute MM098-3D
6.0 mL Predilute MM098-6D
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Description

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular  weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia. Anti-CK8 does not react with skeletal muscle or nerve cells.

Specifications

Alternative Name KRT8, CYK8
Species Mouse
Clone H1 + TS1
Isotype IgG
Dilution Range Assay dependent
Species Reactivity Human
Application IHC
Cell Localization Cytoplasm and Nucleus
Positive Control Lung, Skin, colon or breast carcinoma

DataSheet & SDS

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References

1. . Katsuhide Ikeda et al, Coordinate expression of cytokeratin 8 and cytokeratin 17  immunohistochemical staining in cervical intraepithelial neoplasia and cervical
squamous cell carcinoma: An immunohistochemical analysis and review of the literature. Gynecologic Oncology, March 2008.

 

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