EGFR

EGFR

Pack Size Cat No
0.2 mL Concentrate MM102-AA
1.0 mL Concentrate MM102-CC
3.0 mL Predilute MM102-3D
6.0 mL Predilute MM102-6D
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Description

The epidermal growth factor (EGF) recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 - 4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparinbinding EGF (HB-EGF), amphiregulin, βcellulin and
epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Specifications

Alternative Name EGFR,ERBB,ERBB1,HER1
Species Mouse
Clone 31G7 + GFR1195
Isotype Mouse IgG
Dilution Range Assay dependent
Species Reactivity Human
Application IHC
Cell Localization Cytoplasm and Cell membrane
Positive Control Human Placenta

DataSheet & SDS

Download Data Sheet
Download SDS Sheet

References

1. Petersen I et al, EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC - Experience from the first ring trial of the German Quality
Assurance Initiative for Pathology (QuIP®), Pathol Res Pract. 2017 December.

2. . Clinical and Laboratory Standards Institute. Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline—Third Edition. CLSI document M29-A3 [ISBN 1-56238-567-4].

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