Description

Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Gastric mucin is found in normal  human gastrointestinal tract. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to reexpression of the peptide core of gastric (or fetal colonic)
mucins. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium, small
intestine, gastric cells and gastric metaplasia and it is one of the major mucins in the ethmoid mucosa.