Description

The SOX10 (SRY (sex-determining region Y)-box 10), a member of the Sry HMG box (Sox) family of transcription factors, is essential for maintenance of neural crest progenitor cells and their subsequent differentiation down melanocytic and glial lineages during embryogenesis . Multiple studies have demonstrated that SOX10 is a highly sensitive Immunohistochemical marker of both benign and malignant melanocytic lesions, making it a useful cell lineage indicator in the appropriate clinical context. Nearly 100% of primary melanomas display strong nuclear staining for SOX10 . While SOX10 shows similarly high sensitivity for metastatic melanoma, staining intensity and the percentage of positive nuclei may be lower compared with benign melanocytic lesions and primary melanomas.