Description

Napsin A, a human aspartic proteinase is found primarily in type II pneumocytes and alveolar macrophages and predominantly expressed in lung and kidney. It is a reliable
marker for pulmonary adenocarcinoma and is expressed in a subset of ovarian clear cell carcinomas, endometrial carcinomas, and endometrioid carcinomas .It is also useful in evaluating SH (Sclerosing hemangiomas).Napsin A acts as an anti-apoptotic protein that promotes resistance to cisplatin by degradation of the tumor suppressor p53, which is regulator of the cell cycle and co-works with cyclin kinase inhibitors as p21 and p27.