| Pack Size | Cat No |
|---|---|
| 0.2 mL Concentrate | MM023-AA |
| 1.0 mL Concentrate | MM023-CC |
| 3.0 mL Predilute | MM023-3D |
| 6.0 mL Predilute | MM023-6D |
The P16 (INK4) is a cyclin dependent kinase (Cdk) inhibitor protein. The cell cycle inhibitor proteins family includes P15 (INK4B) P16 (INK4A) P17 (INK4C) P18 (INK4D). P16 expression is commonly associated with cellular senescence. Progression of cell cycle is regulated by a family of Cdk proteins. P16 acts as a repressor for regulation of cell cycle. Its inhibiting activity is thought to be due to the formation of binary & ternary complex
structures with Cdk proteins.
| Alternative Name | p16Ink4A, CDKN2A, CDK 4 Inhibitor ,CDK 4 Inhibitor |
| Species | Mouse |
| Clone | 2D9A12 |
| Isotype | Mouse IgG2b |
| Dilution Range | Assay dependent |
| Species Reactivity | Human, Mouse, Rat |
| Application | IHC |
| Cell Localization | Cytoplasm and Nuclear |
| Positive Control | Human Brain carcinoma, Cervix and Ovarian carcinoma |
1. Sawicka M et al, The Specificity and Patterns of Staining in Human Cells and Tissues of p16INK4a Antibodies Demonstrate Variant Antigen Binding, 2013 January.
2. Chiew-Loon Koo et al, Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study, J Transl Med, 2009 Apr.
