Description

The p53 Tumor Suppressor Protein (DO-7) recognizes a 53 kDa phosphoprotein identified as the p53 suppressor gene product. It reacts with both mutant and wild type p53. It recognizes & binds to the N-terminus (aa 37-45) of p53. The p53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. It is observed that in many transformed cells there is an accumulation of P53 protein which is demonstrated through immune staining. p53 expression is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.