| Pack Size | Cat No |
|---|---|
| 0.2 mL Concentrate | RP033-AA |
| 1.0 mL Concentrate | RP033-CC |
| 3.0 mL Predilute | RP033-3D |
| 6.0 mL Predilute | RP033-6D |
Phosphatase and tensin homolog (PTEN), a negative regulator of the mammalian target of rapamycin (mTOR) pathway, is widely involved in the regulation of protein synthesis .This antibody reacts to human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and has dual specificity to protein phosphatase PTEN. PTEN expression with predisposition to nucleus more frequently observed in HPV-positive tonsillar cancers.
| Alternative Name | MMAC1, TEP1 |
| Species | Rabbit |
| Clone | Polyclonal |
| Isotype | Rabbit IgG |
| Dilution Range | Assay dependent |
| Species Reactivity | Human |
| Application | IHC |
| Cell Localization | Nucleus, Cytoplasm & Membrane |
| Positive Control | Tonsil & Breast carcinoma |
1. JING LI et al, Concomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer, Oncol Lett. 2014, Oct 8, p-1543–1550.
2. Edith A. Perez et al, Impact of PTEN Protein Expression on Benefit from Adjuvant Trastuzumab in Early-Stage Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer in the North Central Cancer Treatment Group N9831 Trial, J Clin Oncol. 2013 Jun 10, p-2115–2122.
3. Daphne Gschwantler-Kaulich et al, PTEN expression as a predictor for the response to trastuzumab-based therapy in Her-2 overexpressing metastatic breast cancer, PLoS One. 2017 Mar.
