RENAL CELL CARCINOMA

RENAL CELL CARCINOMA

Pack Size Cat No
0.2 mL Concentrate MM034-AA
1.0 mL Concentrate MM034-CC
3.0 mL Predilute MM034-3D
6.0 mL Predilute MM034-6D
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Description

RCC antibody is a 200 kDa glycoprotein (gp200) expressed in renal epithelial cells, stains the brush border of proximal renal tubules in human kidneys. Renal cell carcinoma antibody reactivity has been described in up to 93% of primary human renal cell carcinomas and 84% of renal cell carcinoma metastases. The clone 66.4.C2 antibody has also been used to help make a diagnosis of renal cell carcinoma in a horse with a mass of unknown origin. Gp200 is also expressed in breast tubules and ducts, the surface of epididymal tubular epithelia, and the colloid of thyroid follicles

Specifications

Alternative Name CA9, G250, MN
Species Mouse
Clone 66.4.C2
Isotype Mouse IgG2b Kappa
Dilution Range Assay dependent
Species Reactivity Human
Application IHC
Cell Localization Cytoplasmic and Membrane
Positive Control Normal kidney and renal cell
carcinoma tissues

DataSheet & SDS

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References

1. Egbert Oosterwijk et al, Antibody therapy in renal cell carcinoma. World J Urol, 2008 April.

2. Al-Ahmadie, Hikmat A. MD et al, Carbonic Anhydrase IX Expression in Clear Cell Renal Cell Carcinoma: An Immunohistochemical Study Comparing 2 Antibodies. The American Journal of Surgical Pathology, 2008 March.

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