CD45/LCA

CD45/LCA

Pack Size Cat No
0.2 mL Concentrate MM008-AA
1.0 mL Concentrate MM008-CC
3.0 mL Predilute MM008-3D
6.0 mL Predilute MM008-6D
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Description

The CD45 antibody is a Leucocyte common antigen found on lymphoid cells. It is a transmembrane glycoprotein with mol.wt 180-220kDa. CD45 plays complex roles in T cell & B cell antigen receptor signal transduction. Neoplastic cells of B-Cell & T-cell origin stain positive in leukemia & Non-Hodgkin’s lymphomas with CD45 whereas neoplastic cells of myeloid & erythroid stain negative. The localization of this antigen is seems to be on cell membrane . During Lymphoma conditions CD45 is used to screen pan
lymphocytes.

Specifications

Alternative Name PTPRC, CD45
Species Mouse
Clone 2B11
Isotype Mouse IgG1 Kappa
Dilution Range Assay dependent
Species Reactivity Human
Application IHC
Cell Localization Cell membrane
Positive Control Tonsil & Lymphoma

DataSheet & SDS

Download Data Sheet
Download SDS Sheet

References

1. Ann-Catrin Andersson et al, Analysis of Protein
Expression in Cell Microarrays: A Tool for Antibody-based Proteomics, Journal of Histochemistry & Cytochemistry, 2006.

2. Alexander Reta et al, Sensitivity and Specificity of
Antibodies on Necrotic Tumor Tissue, AmJCIinPathol, 1998.

3. El-Sayed et al, Flow cytometric immunophenotyping
(FCI) of lymphoma: correlation with histopathology and
immunohistochemistry, Diagnostic Pathology, 2008.

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